Cloned (Comment) | Organism |
---|---|
gene p450c17, cDNA from ovary, DNA and amino acid sequence determination and analysis, phylogenetic tree, transient expression in COS-7 cells, overexpression in Escherichia coli | Clarias gariepinus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Clarias gariepinus | C7B608 | air-breathing catfish, gene p450c17 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Clarias gariepinus | - |
gill | - |
Clarias gariepinus | - |
gonad | - |
Clarias gariepinus | - |
heart | - |
Clarias gariepinus | - |
interstitial cell | - |
Clarias gariepinus | - |
intestine | - |
Clarias gariepinus | - |
kidney | - |
Clarias gariepinus | - |
additional information | tissue- and developmental stage-dependent expression patterns, overview. p450c17 expression and ratio of lyase to hydroxylase is high in preparatory and pre-spawning phases of ovary and low in spawning phase. Expression of p450c17 correlats well with testicular recrudescence with maximum expression in preparatory and spawning phases. Neither protein expression nor lyase/hydroxylase activity change significantly during hCG-induced oocyte maturation, while in vitro and in vivo though mRNA levels increase | Clarias gariepinus | - |
muscle | - |
Clarias gariepinus | - |
oocyte | - |
Clarias gariepinus | - |
ovarian follicle | - |
Clarias gariepinus | - |
ovary | - |
Clarias gariepinus | - |
spermatocyte | testicular | Clarias gariepinus | - |
spleen | - |
Clarias gariepinus | - |
testis | - |
Clarias gariepinus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | P450c17 is an enzyme type that lacks lyase activity | Clarias gariepinus | ? | - |
? | |
progesterone + 2 NADPH + 2 H+ + 2 O2 | - |
Clarias gariepinus | androstenedione + acetate + 2 NADP+ + 2 H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cytochrome P450 17alpha-hydroxylase/c17-20 lyase | - |
Clarias gariepinus |
P450c17 | - |
Clarias gariepinus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Clarias gariepinus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Clarias gariepinus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Clarias gariepinus |
Organism | Comment | Expression |
---|---|---|
Clarias gariepinus | p450c17 expression and ratio of lyase to hydroxylase is high in preparatory and pre-spawning phases of ovary and low in spawning phase. Expression of p450c17 correlates well with testicular recrudescence with maximum expression in preparatory and spawning phases. Neither protein expression nor lyase/hydroxylase activity change significantly during hCG-induced oocyte maturation, while in vitro and in vivo though mRNA levels increase | up |
General Information | Comment | Organism |
---|---|---|
physiological function | cytochromeP450 17alpha-hydroxylase/c17-20 lyase is one of the key enzymes involved in the steroidogenic shift that occurs prior to oocyte maturation in teleosts | Clarias gariepinus |